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D27 is described as an iron-containing enzyme in the chloroplast that participates in the isomerization of carotenoids, including the conversion of all-trans--carotene to 9-cis--carotene, which is essential for subsequent CCD7 and CCD8 mediated reactions in SL biosynthesis 156

This finding suggests that GLP-1R expression is associated with less possibility of multifocality in PTC and can be considered a good prognostic signal, although the prognostic significance of multifocality in PTC is still controversial

SLs are mainly synthesized in roots via the plastid-localized conversion of all-trans--carotene to carlactone by the sequential action of CCD7, CCD8, and D27 enzymes, and then transported to aerial parts 144

Cardiac function: thyroid hormones influence the expression of genes that regulate heart rate and contractility

doi:10.1172/jci.insight.133429 37

doi:10.2337/diabetes.50.3.609 309